Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 15 de 15
Filter
1.
Rev. bras. educ. méd ; 47(2): e061, 2023. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1449608

ABSTRACT

Abstract: Introduction: It was found that the good performance in conventional techniques was not transferable to minimally-invasive alternatives, and then simulators were created for improved learning. Objective: To assess whether robotic virtual reality simulation conditions ability for laparoscopy in medical students, associating the VARK tool and Mind Styles to determine whether there is a correlation between learning styles and the ability to develop these skills. Methods: Randomization of 3 groups of medical students was performed, where one of the groups performed a simulation of a surgical knot exercise in the laparoscopy box and another, the same exercise on the robot console. The third group did not simulate. All participants took a practical test in the laparoscopy box and their performances were evaluated. Moreover, a pre-test and a post-test were applied, in addition to the VARK and mind styles methods, to assess whether there was a difference in performance between the different learning styles. Results: The practical test scores were relatively homogeneous between the groups and between the Mind Styles and VARK categories, with no significant difference being found between the groups; therefore, it was not possible to demonstrate that learning styles interfered with the results of this study. There was only a significant difference between the pre-test scores of at least one pair of the groups and between the Laparoscopy and Robotics groups, with a p-value of 0.038. Conclusion: There was no statistical significance between learning styles and performance regarding the proposed tasks.


Resumo: Introdução: Constatou-se que o bom desempenho em técnicas convencionais não se transferia para as minimamente invasivas, e, com isso, foram criados os simuladores para melhor aprendizado. Objetivo: Este estudo teve como objetivo avaliar se a simulação em realidade virtual robótica promove habilidade para laparoscopia em acadêmicos de Medicina, associando a ferramenta VARK e o mind styles (GSD) para determinar se há correlação dos estilos de aprendizagem com a capacidade de desenvolver essas habilidades. Método: Realizou-se randomização de três grupos de acadêmicos de Medicina, em que um dos grupos fez simulação de um exercício de nó cirúrgico na caixa de laparoscopia (CL), e outro, o mesmo exercício no console do robô. O terceiro grupo não participou da simulção. Todos os participantes fizeram um teste prático na CL, e as performances deles foram avaliadas. Ademais, foram aplicados um pré-teste e um pós-teste, além do formulário VARK e GSD, para avaliar se havia diferença de performance entre os diferentes estilos de aprendizagem. Resultado: As notas das provas práticas foram relativamente homogêneas entre grupos e entre as categorias de Mind Styles e do VARK. Como não se encontrou diferença significativa entre os grupos, não foi possível demonstrar que os estilos de aprendizagem interferiram nos resultados deste estudo. Houve apenas diferença significativa entre as notas do pré-teste de pelo menos um par de grupos e entre os grupos laparoscopia e robótica com p-valor 0,038. Conclusão: Não houve significância estatística entre os estilos de aprendizagem e o desempenho nas tarefas propostas.

2.
Fisioter. Bras ; 23(2): 288-304, mai 19, 2022.
Article in Portuguese | LILACS-Express | LILACS | ID: biblio-1436266

ABSTRACT

Objetivo: Analisar a adesão de mulheres incontinentes à fisioterapia pélvica auxiliada por smartphone (aplicativo), em comparação a abordagens tradicionais. Métodos: Estudo longitudinal randomizado controlado de 128 mulheres: G1 fisioterapia face a face auxiliada por aplicativo; G2 fisioterapia face a face e folha de exercícios impressa; G3 aplicativo somente e G4 folha impressa somente. Realizadas 12 sessões de fisioterapia face a face, em grupo, uma vez por semana, durante 3 meses. Resultados: 77 (60,2%) aderiram ao tratamento e 51 (39,8%) não. Os aderentes tinham em média 48,3 anos, contra 44,5 das não aderentes (p = 0,015). Houve menor adesão às metodologias síncronas: G1, 19 (50%), G2, 21 (28,8%), quando comparadas às assíncronas: G3, 3 (13,6%), e no G4, 8 (32%) (p = 0,025). Fumantes (71,4%) e usuárias de álcool (53,85%) não aderiram (p = 0,002 e p = 0,016 respectivamente). 50 mulheres apresentaram IU de esforço, 67 IU mista e 11 IU de urgência, não correlacionada à adesão (p = 0,06). Nenhuma das mulheres não aderentes possuiu renda superior a 6 salários-mínimos. Conclusão: A adesão ao treinamento muscular do assoalho pélvico é maior quando a fisioterapia é associada a um aplicativo móvel. O tabagismo, o consumo de álcool e a categoria de renda impactam negativamente na adesão.

3.
Rev. Col. Bras. Cir ; 49: e20223233, 2022. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1394614

ABSTRACT

ABSTRACT Objective: to evaluate the renal toxicity caused by tacrolimus and mycophenolate mofetil (MMF) in a single kidney ischemia and reperfusion model. Method: experimental study using Wistar rats, submitted to right nephrectomy and left renal ischemia for 20 minutes, separated into groups in the postoperative period (PO): 1) Control (nonoperated); 2) Sham (operated, without PO drug); 3) TAC0.1, TAC1 and TAC10, tacrolimus administered PO at doses of 0.1mg/kg, 1mg/kg and 10mg/kg via gavage, respectively; 4) MMF, administered mycophenolate mofetil 20mg/kg; 5) MMF/TAC1 and MMF/TAC0.5, with an association of mycophenolate mofetil 20mg/kg and tacrolimus 1mg/kg and 0.5mg/kg, respectively. They were killed on the 14th PO and the kidney was removed for tissue oxidative stress analysis, by the dosage of reduced glutathione (GSH), lipoperoxidation (LPO) and protein carbonylation (PCO), and histological analysis by glomerular stereology (Glomerular volume density, Numerical density glomerular and mean glomerular volume). Renal function was evaluated by the measurement of serum creatinine and urea. Results: both drugs caused alterations in renal function, and the toxicity of tacrolimus was dose-dependent. Subacute toxicity did not show significant glomerular histological changes, and there was renal and compensatory glomerular hypertrophy in all groups except TAC10. Conclusion: Both drugs cause changes in renal function. Glomerular morphometry and stereology showed negative interference of immunosuppressants during compensatory glomerular hypertrophy.


RESUMO Objetivo: avaliar a toxicidade renal causada pelo tacrolimus e micofenolato mofetil (MMF) em um modelo de isquemia e reperfusão de rim único. Método: estudo experimental utilizando ratos Wistar, submetidos á nefrectomia direita e isquemia renal esquerda por 20 minutos, separados em grupos no pós- operatório (PO): 1) Controle (não operados); 2) Sham (operados, sem droga PO); 3) TAC0.1, TAC1 e TAC10, administrado tacrolimus no PO nas doses 0,1mg/kg, 1mg/kg e 10mg/kg via gavagem, respectivamentae; 4) MMF, administrado micofenolato mofetil 20mg/kg; 5) MMF/TAC1 e MMF/TAC0.5, com associação de micofenolato mofetil 20mg/kg e tacrolimus 1mg/kg e 0,5mg/kg, respectivamente. Foram mortos no 14º PO e retirado rim para análise do estresse oxidativo tecidual, pela dosagem de glutationa reduzida (GSH), lipoperoxidação (LPO) e carbonilação de proteínas (PCO), e análise histológica por estereologia glomerular (Densidade de volume glomerular, Densidade numérica glomerular e Volume glomerular médio). Foi avaliada função renal pela dosagem de creatinina e uréia séricas. Resultados: ambas drogas provocaram alteração na função renal, sendo a toxicidade do tacrolimus dosedependente. A toxicidade subaguda não mostrou alterações histológicas glomerulares significativas, sendo que houve hipertrofia renal e glomerular compensatória em todos os grupos exceto em TAC10. Conclusão: Ambas drogas provocam alteração na função renal. A morfometria e a estereologia glomerular mostraram interferência negativa dos imunossupressores durante a hipertrofia glomerular compensatória..

4.
Acta cir. bras ; 35(11): e351103, 2020. ilus, tab, graf
Article in English | LILACS, VETINDEX | ID: biblio-1456240

ABSTRACT

Purpose To evaluate renal histological changes by stereology and morphometry and analyze the main markers of oxidative stress in rats undergoing natural aging. Methods Seventy two Wistar rats were divided into six groups of 12 rats each, which were euthanized at 3, 6, 9, 12, 18, and 24 months of age. Right kidney was stereologically and morphometrically analyzed to calculate the volumetric density (Vv[glom]), numerical density (Nv[glom]) and glomerular volume (Vol[glom]). Left kidney was used to determine the levels of nonprotein thiols, lipid peroxidation, and protein carbonylation, as well as the activities of superoxide-dismutase and catalase enzymes. Results Both Vv[glom] and Nv[glom] values showed gradual decreases between groups. Activity of superoxide-dismutase was elevated at 24 months of age, and the levels of nonprotein thiols were higher in older animals. Greater catalase activity and protein carbonylation were observed in animals between 6 and 12 months of age but lessened in older rats. Lipid peroxidation decreased in the older groups. Conclusions Morphometric and stereological analyses revealed a gradual decrease in the volume and density of renal glomeruli during aging, as well as kidney atrophy. These findings related to oxidative stress clarify many changes occurring in kidney tissues during senescence in rats.


Subject(s)
Animals , Rats , Aging , Oxidative Stress , Kidney Diseases/veterinary
5.
Acta cir. bras ; 35(11): e351106, 2020. tab, graf
Article in English | LILACS | ID: biblio-1141941

ABSTRACT

Abstract Purpose To evaluate renal histological changes by stereology and morphometry and analyze the main markers of oxidative stress in rats undergoing natural aging. Methods Seventy two Wistar rats were divided into six groups of 12 rats each, which were euthanized at 3, 6, 9, 12, 18, and 24 months of age. Right kidney was stereologically and morphometrically analyzed to calculate the volumetric density (Vv[glom]), numerical density (Nv[glom]) and glomerular volume (Vol[glom]). Left kidney was used to determine the levels of nonprotein thiols, lipid peroxidation, and protein carbonylation, as well as the activities of superoxide-dismutase and catalase enzymes. Results Both Vv[glom] and Nv[glom] values showed gradual decreases between groups. Activity of superoxide-dismutase was elevated at 24 months of age, and the levels of nonprotein thiols were higher in older animals. Greater catalase activity and protein carbonylation were observed in animals between 6 and 12 months of age but lessened in older rats. Lipid peroxidation decreased in the older groups. Conclusions Morphometric and stereological analyses revealed a gradual decrease in the volume and density of renal glomeruli during aging, as well as kidney atrophy. These findings related to oxidative stress clarify many changes occurring in kidney tissues during senescence in rats.


Subject(s)
Animals , Rats , Catalase/metabolism , Superoxide Dismutase/metabolism , Aging , Lipid Peroxidation , Rats, Wistar , Oxidative Stress , Kidney/metabolism , Kidney Diseases
6.
Rev. bras. educ. méd ; 43(3): 134-144, jul.-set. 2019. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1003430

ABSTRACT

ABSTRACT In recent years, Multiple Intelligences (MI - bodily-kinesthetic, spatial, intrapersonal, interpersonal, linguistic, logical-mathematical, musical, and naturalist) and Learning Preferences (LP - visual, aural, read/write, kinesthetic, and multimodal) have been intensely studied throughout the world. In this context, plenty of tools that evaluate such parameters have been created and later improved over the past decades. Nowadays, the necessity for optimal learning strategies and more individualized teaching continues to rise, reinforcing the importance of identifying individual strengths and cognitive preferences. Objectives to analyze the distribution of MI - and how they influence one another - and LP in medical students at the Federal University of Paraná (UFPR), Brazil. The results could lead to improvements in the educational setting. Methods a descriptive cross-sectional study involving UFPR medical students of all 12 semesters, who were analyzed through questionnaires with regard to both their MI ("Multiple Intelligences Checklist for Students") and LP ("Visual, Aural, Read/Write, Kinesthetic - VARK - Questionnaire"). Results a total of 1054 questionnaires were processed (527 students). Intrapersonal (71 ± 10.5), logical-mathematical (69.3 ± 14), and linguistic (68.4 ± 11.8) intelligences predominated, whereas naturalist achieved the lowest mean score (47.3 ± 19.5). Positive correlations were identified between all of the MI. Regarding the LP, the multimodal (42.3%) was the most frequent, followed by visual (21.3%), aural (18.6%), kinesthetic (11.2%), and read/write (6.6%). When both cognitive theories were correlated, the following associations prevailed: visual LP and intrapersonal intelligence; aural LP and interpersonal intelligence; read/write LP and logical-mathematical intelligence; kinesthetic LP and logical-mathematical intelligence; and multimodal preference and intrapersonal intelligence. Conclusions intrapersonal intelligence achieved the highest overall scores, followed by logical-mathematical and linguistic. Naturalist intelligence achieved the lowest scores in terms of semester, cycle, and overall analysis. All MI were positively correlated. Multimodality was the most commonly observed LP, whereas the read/write preference was the least frequent. Correlations initially expected between MI and LP were confirmed. As for future perspectives, it is expected that teachers and education managers adapt current teaching strategies in order to meet the students' preferences. Together, MI and LP indicate that the focus should not rely on how smart a given person is, but in which ways.


RESUMO Nos últimos anos, Inteligências Múltiplas (IM - corporal-cinestésica, espacial, intrapessoal, interpessoal, linguística, lógico-matemática, musical e naturalista) e Preferências de Aprendizagem (PA - visual, auditiva, leitura/escrita, cinestésica, multimodal) vêm sendo intensamente estudadas em todo o mundo. Em tal contexto, diversas ferramentas que avaliassem tais parâmetros foram criadas e posteriormente aprimoradas ao longo das últimas décadas. Atualmente, a necessidade de se utilizar as melhores estratégias de aprendizado e a crescente necessidade de que o ensino seja individualizado reforçam a importância de que sejam mapeadas as habilidades e preferências cognitivas individuais. Objetivos analisar as distribuições de IM - e como elas se influenciam - e das PA em estudantes de medicina da Universidade Federal do Paraná (UFPR), Brasil. Espera-se que os resultados estimulem melhorias no contexto educacional. Materiais e Métodos estudo transversal e descritivo envolvendo estudantes de medicina da UFPR de todos os 12 semestres, sendo analisados através de questionários quanto às suas MI e ("Lista de verificação para avaliar inteligências múltiplas de alunos") e PA ("Visual, Aural, Read/Write, Kinesthetic - VARK - Questionnaire", previamente traduzido e validado para a língua Portuguesa). Resultados 1054 questionários foram coletados e processados. As IM intrapessoal (71±10,5), lógico-matemática (69,3±14) e linguística (68,4±11,8) atingiram as maiores médias gerais, enquanto a naturalista registrou a menor pontuação (47,3±19,5). Observou-se correlação positiva entre todas as IM. Quanto às PA, prevaleceu a multimodal (42,3%), seguida por visual (21,3%), auditiva (18,6%), cinestésica (11,2%) e leitura/escrita (6,6%). Quando correlacionadas ambas as teorias cognitivas, sobressaíram-se as seguintes associações: PA visual e IM intrapessoal; PA auditiva e IM interpessoal; PA leitura/escrita e IM lógico-matemática; PA cinestésica e IM lógico-matemática; e PA multimodal e IM intrapessoal. Conclusão A IM intrapessoal atingiu maiores médias, seguida por lógico-matemática e linguística. A IM naturalista, por outro lado, obteve menores pontuações em termos de semestres, ciclos e análise geral. Todas as inteligências apresentaram influência apresentaram interdependência positiva. A multimodalidade foi a PA mais prevalente, enquanto leitura/escrita foi a menos observada. Correlações inicialmente esperadas entre IM e PA foram confirmadas. Quanto às perspectivas futuras, espera-se que professores e gestores educacionais adaptem estratégias de ensino atuais de modo a melhor contemplar as preferências dos estudantes. Em conjunto, IM e PA preconizam que atualmente não mais se questione o quão inteligente alguém seja, e sim de que maneiras o seria.

7.
Acta cir. bras ; 34(8): e201900803, 2019. graf
Article in English | LILACS | ID: biblio-1038126

ABSTRACT

Abstract Purpose To evaluate changes in the quantity of elastic fibers in the corpora cavernosa of rats during the natural aging process, and to assess the degree of this change by determining volumetric density (Vv) at different ages via stereological analysis. Methods Forty-eight rats, raised under similar conditions, were subjected to the natural aging process and divided into four groups (G1 to G4), according to age at the time of penectomy (6, 9, 12, and 24 months, respectively). Histological sections of the middle segment of the penis were stained with Weigert's resorcin-fuchsin, and the volumetric density (Vv) of elastic fibers of the corpora cavernosa were determined via stereological analysis. Results There were no statistically significant differences in Vv among groups G1, G2, and G3. These three groups were therefore considered as a single group. The mean Vv of this group showed a statistically significant reduction compared to that of G4 (0.16 vs. 0.11, p<0.05). Conclusion Natural aging in rats was responsible for a reduction in volumetric density of elastic fibers of the corpora cavernosa (approximately 30% decrease in Vv) during senescence.


Subject(s)
Animals , Male , Rats , Penis/cytology , Aging/physiology , Endothelial Cells/physiology , Elastic Tissue/ultrastructure , Penis/physiology , Aging/pathology , Collagen/physiology , Collagen/ultrastructure , Rats, Wistar , Models, Animal , Elastic Tissue/physiology , Elastic Tissue/pathology , Erectile Dysfunction/physiopathology
8.
Acta cir. bras ; 33(10): 904-913, Oct. 2018. tab, graf
Article in English | LILACS | ID: biblio-973466

ABSTRACT

Abstract Purpose: To quantify, through stereological and morphometric analysis, spermatogenesis in rats undergoing the natural aging process. Methods: Seventy-two male Wistar rats were divided into 6 equal groups according to age at the time of killing: 3, 6, 9, 12, 18, and 24 months. All the rats were subjected orchiectomy and collection of testicular parenchymal fragments for histological and morphometric analysis. The numerical density of spermatids was calculated using a stereological study, and morphometric analysis was conducted to measure the height of the germinal epithelium and the area of the seminiferous tubules. Results: We found that the 18 and 24 months groups showed a significant reduction in the number of round spermatids. However, the height of the germinal epithelium was not significantly different between the groups. The area of seminiferous tubules was also significantly reduced in the elderly rats compared to that in the young ones. Conclusion: Aging of rats showed a significant reduction in the number of round spermatids and the area of the seminiferous tubules, more pronounced in the rats at 18 and 24 months of life.


Subject(s)
Animals , Male , Rats , Seminiferous Tubules/anatomy & histology , Spermatids/physiology , Spermatogenesis/physiology , Aging/physiology , Seminiferous Tubules/surgery , Seminiferous Tubules/physiology , Sperm Count , Orchiectomy , Rats, Wistar , Disease Models, Animal
9.
Acta cir. bras ; 32(10): 807-815, Oct. 2017. tab, graf
Article in English | LILACS | ID: biblio-886170

ABSTRACT

Abstract Purpose: To analyze the effects of aging in rats on the nuclear volume, cytoplasmic volume, and total volume of Leydig cells, as well as their number. Methods: Seventy-two Wistar rats were divided into six subgroups of 12 rats, which underwent right orchiectomy at 3, 6, 9, 12, 18, and 24 months of age. The weight and volume of the resected testicles were assessed. A stereological study of Leydig cells was conducted, which included measurements of cell number and nuclear, cytoplasmic, and total cell volumes. Results: The weight and volume of the resected testicles showed reductions with age. Only the subgroup composed of 24-month old rats showed a decrease in the nuclear volume of Leydig cells. Significant reductions in the cytoplasmic volume and total volume of Leydig cells were observed in 18- and 24-month old rats. The number of Leydig cells did not vary significantly with age. Conclusions: Aging in rats resulted in reduction of the nuclear, cytoplasmic, and total cell volumes of Leydig cells. There was no change in the total number of these cells during aging.


Subject(s)
Animals , Male , Rats , Aging/physiology , Leydig Cells/pathology , Orchiectomy , Cell Count , Rats, Wistar
10.
Acta cir. bras ; 31(5): 346-352, May 2016. tab, graf
Article in English | LILACS | ID: lil-783799

ABSTRACT

ABSTRACT PURPOSE: To evaluate the renal function and the renal histological alterations through the stereology and morphometrics in rats submitted to the natural process of aging. METHODS: Seventy two Wistar rats, divided in six groups. Each group was sacrificed in a different age: 3, 6, 9, 12, 18 and 24 months. It was performed right nephrectomy, stereological and morphometric analysis of the renal tissue (renal volume and weight, density of volume (Vv[glom]) and numerical density (Nv[glom]) of the renal glomeruli and average glomerular volume (Vol[glom])) and also it was evaluated the renal function for the dosage of serum creatinine and urea. RESULTS: There was significant decrease of the renal function in the oldest rats. The renal volume presented gradual increase during the development of the rats with the biggest values registered in the group of animals at 12 months of age and significant progressive decrease in older animals. Vv[glom] presented statistically significant gradual reduction between the groups and the Nv[glom] also decreased significantly. CONCLUSIONS: The renal function proved to be inferior in senile rats when compared to the young rats. The morphometric and stereological analysis evidenced renal atrophy, gradual reduction of the volume density and numerical density of the renal glomeruli associated to the aging process.


Subject(s)
Animals , Male , Aging/physiology , Kidney/anatomy & histology , Kidney/physiology , Organ Size/physiology , Urea/blood , Rats, Wistar , Creatinine/blood , Evaluation Studies as Topic , Kidney Glomerulus/physiopathology
11.
Braz. j. otorhinolaryngol. (Impr.) ; 82(1): 47-55, Jan.-Feb. 2016. tab, graf
Article in Portuguese | LILACS | ID: lil-775706

ABSTRACT

ABSTRACT INTRODUCTION: In rhinoplasty, facial esthetic analysis is critical for proper surgical planning. Parameters such as rotation and nasal projection should be routinely evaluated. Few studies have objectively assessed changes in facial angles postoperatively. OBJECTIVE: To evaluate the effectiveness of medial intercrural sutures and of rotation of the nasal tip on the increase of rotation and nasal projection in Caucasian patients undergoing primary rhinoplasty. METHODS: A prospective study carried out between 2011 and 2013, with 27 patients treated with primary rhinoplasty with a basic technique by the same surgeon, with medial intercrural sutures and rotation of the nasal tip. Rotation and nasal projection were measured from photographs obtained preoperatively and after 12 months. RESULTS: All 27 patients completed the study. The mean age was 27.1 years. There was a mean increase of 8.4° in the rotation - a statistically significant value. There was no significant change in the projection. CONCLUSION: The medial intercrural and nasal tip rotation sutures are effective in increasing nasal rotation in Caucasian patients undergoing rhinoplasty.


RESUMO INTRODUÇÃO: Na rinoplastia, a análise estética facial é essencial para um planejamento cirúrgico adequado. Parâmetros como rotação e projeção nasal devem ser rotineiramente avaliados. Há poucos estudos que avaliem objetivamente as mudanças nos ângulos faciais no pós-operatório. OBJETIVO: Avaliar a eficácia das suturas intercrura mediais e de rotação da ponta nasal no aumento da rotação e projeção nasal em pacientes caucasianos submetidos à rinoplastia primária. MÉTODO: Estudo prospectivo realizado entre 2011 e 2013, com 27 pacientes submetidos à rinoplastia primária técnica básica, pelo mesmo cirurgião, com suturas intercrura mediais e de rotação da ponta nasal. Mediu-se a rotação e a projeção nasal a partir de fotografias no pré-operatório e 12 meses após. RESULTADOS: Todos os 27 pacientes completaram o estudo. A idade média foi de 27,1 anos. Houve aumento médio de 8,4° na rotação, com significância estatística. Não houve alteração significativa na projeção. CONCLUSÃO: As suturas intercrura mediais e de rotação da ponta nasal são eficazes no aumento da rotação nasal em pacientes caucasianos submetidos à rinoplastia.


Subject(s)
Adult , Female , Humans , Male , Nasal Septum/surgery , Rotation , Rhinoplasty/methods , Suture Techniques , Esthetics , White People , Postoperative Period , Prospective Studies
12.
Acta cir. bras ; 30(2): 127-133, 02/2015. tab, graf
Article in English | LILACS | ID: lil-741031

ABSTRACT

PURPOSE: To evaluate renal histological changes and renal function in single kidney rats submitted to renal ischemia-reperfusion and to immunosuppression with tacrolimus and mycophenolate-mofetil. METHODS: Experimental study with 80 Wistar rats distributed into control, Sham and six other groups treated with immunosuppressive drugs. Animals undergoing surgery, right nephrectomy and left renal clamping, killed on the 14th day and analyzed for renal histology, urea and creatinine. RESULTS: The group receiving tacrolimus at higher doses (T3) showed renal histological lesions indicative of early nephrotoxicity, and significant increase in urea and creatinine. The group M (mycophenolate-mofetil alone) and the group M2 (mycophenolate-mofetil combined with half the usual dose of tacrolimus) presented a slight rise in serum urea. The groups using mycophenolate-mofetil alone or combined with tacrolimus showed creatinine levels similar to that of the group T3. CONCLUSIONS: Histologically, the association of injury by ischemia-reperfusion with the use of tacrolimus or mycophenolate-mofetil alone demonstrated a higher rate of renal changes typical of early nephrotoxicity. In laboratory, the combination of injury by ischemia-reperfusion with tacrolimus at higher doses proved to be nephrotoxic. .


Subject(s)
Animals , Male , Immunosuppressive Agents/adverse effects , Ischemia/complications , Kidney Diseases/etiology , Kidney/blood supply , Mycophenolic Acid/analogs & derivatives , Reperfusion Injury/complications , Tacrolimus/adverse effects , Calcineurin Inhibitors/adverse effects , Creatinine/blood , Immunosuppression Therapy/adverse effects , Immunosuppressive Agents/blood , Kidney Diseases/pathology , Kidney Diseases/physiopathology , Kidney/pathology , Mycophenolic Acid/adverse effects , Nephrons/drug effects , Random Allocation , Rats, Wistar , Time Factors , Tacrolimus/blood , Urea/blood
13.
Acta cir. bras ; 29(8): 508-514, 08/2014. tab, graf
Article in English | LILACS | ID: lil-719189

ABSTRACT

PURPOSE: To evaluate bladder histology in healing and biochemical analysis of rats with single kidney in ischemia/reperfusion, treated with tacrolimus. METHODS: Fifty rats randomized into five groups. Three rats died in surgery, 47 rats divided in groups: Control (non-operated, n=10), Sham (operated without drugs, n=8), T1 (operated + tacrolimus 1mg/kg, n=10), T2 (operated + tacrolimus 0.1 mg/kg, n=10), T3 (operated + tacrolimus 10mg/kg, n=9). The surgery was: laparotomy, right nephrectomy, left kidney ischemia/reperfusion, cystotomy followed by bladder suture. After that, rats were submited to gavage daily (Control and Sham with saline solution. T1, T2, T3 with tacrolimus in doses already mentioned). On the 14th day, after death induction, cystectomy was performed and bladder was histologicaly analysed. The serum urea, creatinine and tacrolimus were analysed too. RESULTS: There was difference in serum tacrolimus in T3 compared to the other groups (p<0.05). There was higher doses of creatinine in T3 group and higher urea in groups with tacrolimus. There were significant differences among all histologic variables comparing groups with and without tacrolimus (p<0.05). CONCLUSION: Tacrolimus associated with ischemia/reperfusion is nephrotoxic, suppresses inflammation and seems to delay the healing bladder. .


Subject(s)
Animals , Male , Cicatrix/drug therapy , Immunosuppressive Agents/therapeutic use , Ischemia/complications , Kidney/blood supply , Tacrolimus/therapeutic use , Urinary Bladder/drug effects , Blood Urea Nitrogen , Cicatrix/pathology , Creatinine/blood , Immunosuppressive Agents/pharmacology , Models, Animal , Nephrectomy , Random Allocation , Rats, Wistar , Reperfusion Injury/complications , Tacrolimus/pharmacology , Urinary Bladder/pathology , Wound Healing/drug effects , Wound Healing/physiology
14.
Rev. bras. educ. méd ; 35(4): 502-506;, out.-dez. 2011. ilus
Article in Portuguese | LILACS | ID: lil-613507

ABSTRACT

A anatomia é considerada matéria essencial à educação médica. Aulas práticas com uso de componentes anatômicos manipuláveis são fundamentais ao ensino e à aprendizagem. O objetivo deste estudo foi avaliar o Modelo Sintético de Pelve (Masp) como ferramenta didática, comparada à pelve cadavérica (PC) tradicionalmente utilizada, bem como a satisfação dos estudantes em relação a ambos os métodos. Sessenta e sete estudantes receberam aula teórica após teste teórico preliminar (TTP). Foram randomizados em três grupos: G1 teve aula prática tradicional (APT); G2, aula prática com Masp (APM); e G3 não teve aula prática. Um teste final (TTF) foi aplicado a todos os grupos. G1 e G2 submeteram-se à avaliação do método (AM). A análise estatística foi realizada utilizando-se Anova (Análise de Variância) e teste não paramétrico Mann-Whitney. No TTF, G3 apresentou escores mais baixos do que G1 (p = 0,041) e G2 (p = 0,000). Não foi encontrada diferença estatisticamente significante entre G1 e G2 (p >0,05). G2 apresentou maior satisfação com o método (p = 0,001). Concluiu-se que PC e Masp provaram ser ferramentas didáticas efetivas e que G2 mostrou maior satisfação.


Anatomy is considered a fundamental subject of medical education. Practical classes which involve the use of manipulable anatomic components are essential to teaching and learning. The aim of this study was to evaluate the synthetic pelvic model (SPM) as a didactic tool, compared to the traditionally- -used cadaveric pelvis (CP), as well as student satisfaction in relation to both methods. Sixty-seven students were given a theory class following the preliminary theoretical test (PTT). The study sample was randomized in three groups: G1 had a traditional practical class (TPC); G2 had a practical class with SPM (PCS); and G3 had no practical class. A final test (FTT) was applied to all the groups. G1 and G2 were subjected to method evaluation (ME). Statistical analysis was conducted using analysis of variance (ANOVA) and the Mann-Whitney U test. In the FTT, G3 presented scores lower than G1 (p = 0.041) and G2 (p = 0.000). No statistically significant difference was found between G1 and G2 (p >0.05). G2 presented greater satisfaction with the method (p = 0.001). In conclusion, both CP and SPM proved to be effective didactic tools and student satisfaction was greater with G2.


Subject(s)
Humans , Anatomy/education , Pelvic Floor/anatomy & histology , Education, Medical , Models, Anatomic , Students, Medical , Teaching Materials
15.
Int. braz. j. urol ; 29(4): 353-359, July-Aug. 2003. ilus, tab
Article in English | LILACS | ID: lil-359139

ABSTRACT

INTRODUCTION: SAFIRE TM is a readjustable and minimally invasive sling for the treatment of stress urinary incontinence (SUI). It is as a pubovaginal sling placed in the medial third of the urethra. The initial experience is described. MATERIALS AND METHODS: Forty-five patients (mean age = 59 years) underwent a SAFYRE TM implant to treat SUI. Physical examination and urodynamic study were performed before surgery. All patients presented symptoms of SUI and 20 percent also reported mild urgency. Approximately 60 percent of this group had a previously failed anti-incontinence procedure. Urethral hypermobility was diagnosed in 40 percent of the patients and intrinsic sphincter deficiency (ISD) in 60 percent of the cases. RESULTS: The average follow up period was 10 months. The mean operative time was 20 minutes. Dystopia repair was performed whenever necessary, during the same procedure. The average hospital stay was 24 hours. In 11 percent of the implants, bladder perforation occurred. During the postoperative period, 9 patients (20 percent) developed transient urgency symptoms. During the initial follow up period, 90 percent were found to be continent, 3 percent reported an improvement and 7 percent were unchanged. CONCLUSION: SAFYRE TM is a safe and quick procedure that allows postoperative readjustment. This technique may be an attractive alternative in the management of SUI, should the good result obtained so far prove to be long lasting.

SELECTION OF CITATIONS
SEARCH DETAIL